This product is manufactured by Benchmark Scientific Inc. According to the supplier, proteins will generally survive the bead-beating process. It is recommended to monitor heat build-up. Start with all components cold and run the unit in short bursts with a rest between cycles. Don't overprocess the samples. If these guidelines are followed, multi-subunit enzymes can retain activity following bead beating. However, if the protein is membrane-bound, disruption may cause denaturation.
For more information on this product, please view the manufacture website and data sheet below:
https://www.benchmarkscientific.com/product/d2400/
https://www.benchmarkscientific.com/wp-content/uploads/2020/10/BeadBlaster-24-jpgs-literature-rpm.pdf