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I3875

Sigma-Aldrich

Indoxyl sulfate potassium salt

Synonym(s):

Potassium 3-indoxyl sulfate, Urinary indican

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About This Item

Linear Formula:
C8H6NO4SK
CAS Number:
2642-37-7
Molecular Weight:
251.30
Beilstein:
3921324
EC Number:
220-145-5
MDL number:
MFCD00037931
UNSPSC Code:
12352100
PubChem Substance ID:
57654302
NACRES:
NA.22

mp

165 °C (dec.) (lit.)

storage temp.

−20°C

SMILES string

[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12

InChI

1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1

InChI key

MDAWATNFDJIBBD-UHFFFAOYSA-M

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General description

Indoxyl sulfate potassium salt is derived from indoxyl sulfate by replacing the hydrogen ion with a potassium cation. Potassium indoxyl sulfate is used as a reagent for the detection and determination of hydrogen peroxide.

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Indoxyl-sulfate activation of the AhR-NF-$\kappa$B pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve
Candellier, et al.
Journal of Molecular and Cellular Cardiology, 179, 18-29 (2023)
Bummei Sato et al.
The American journal of cardiology, 111(5), 712-716 (2012-12-12)
The prognosis of patients with diastolic heart failure (HF) is as poor as that of patients with systolic HF. Greater chronic kidney disease-associated mortality occurs in patients with left ventricular (LV) diastolic HF than in those with systolic HF. Indoxyl
Binding affinity and capacity for the uremic toxin indoxyl sulfate
Devine, et al.
Toxins, 6, 416-429 (2014)
Tetsuhiro Tanaka et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(10), 4059-4075 (2013-06-25)
Chronic hypoxia in the tubulointerstitium serves as a final common pathway in progressive renal disease. Circumstantial evidence suggests that hypoxia-inducible factor (HIF)-1 in the ischemic tubules may be functionally inhibited in a chronic kidney disease (CKD) milieu. In this study
Hidehisa Shimizu et al.
Life sciences, 92(2), 143-148 (2012-12-04)
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in adhesion of monocytes/macrophages to injured tubulointerstitial tissue. The present study aimed to determine if indoxyl sulfate, a uremic toxin, regulates renal expression of ICAM-1. The effect of indoxyl sulfate on
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