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96895

Sigma-Aldrich

Z-Lys-ONp hydrochloride

≥98.0% (AT)

Synonym(s):

Nα-Z-L-lysine 4-nitrophenyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H23N3O6 · HCl
CAS Number:
2179-15-9
Molecular Weight:
437.87
Beilstein:
7191805
EC Number:
218-546-5
MDL number:
MFCD00039055
UNSPSC Code:
12352200
PubChem Substance ID:
57653793
NACRES:
NA.22

Assay

≥98.0% (AT)

form

powder

optical activity

[α]20/D −24±1°, c = 1% in DMF

mp

146-152 °C

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

Cl.NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O

InChI

1S/C20H23N3O6.ClH/c21-13-5-4-8-18(22-20(25)28-14-15-6-2-1-3-7-15)19(24)29-17-11-9-16(10-12-17)23(26)27;/h1-3,6-7,9-12,18H,4-5,8,13-14,21H2,(H,22,25);1H/t18-;/m0./s1

InChI key

JFZLPXVXTZKFDV-FERBBOLQSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S Buus et al.
Journal of immunology (Baltimore, Md. : 1950), 136(2), 452-458 (1986-01-01)
A limited intralysosomal proteolytic degradation is probably a key event in the accessory cell processing of large protein antigens before their presentation to T cells. With the aid of highly specific inhibitors of proteinases, we have examined the role of
J P Malthouse et al.
The Biochemical journal, 215(3), 555-563 (1983-12-01)
A detailed study of the kinetics of the trypsin (EC 3.4.21.4)-catalysed hydrolysis of N-alpha-benzyloxycarbonyl-L-lysine p-nitrophenyl ester in cryosolvents at 0 degrees C and below was undertaken. The pH-dependences of kcat, Km, k+2, k+3 and Ks were determined under cryoenzymological conditions
P Ascenzi et al.
Biochimica et biophysica acta, 915(3), 421-425 (1987-10-15)
A titration method for determination of trypsin-like serine proteinase concentration has been developed by using ZArgONp and ZLysONp, two specific chromogenic amino-acid derivatives which show the characteristics of optimal active-site titrants. Active proteinase concentration has been estimated from the effect
N E Mackenzie et al.
The Biochemical journal, 219(2), 437-444 (1984-04-15)
The kinetics of the trypsin-catalysed hydrolysis of the highly specific substrate N alpha-benzyloxycarbonyl-L-lysine p-nitrophenyl ester were studied under cryoenzymological conditions by 13C-n.m.r. spectroscopy at pH approx. 3.0. The kinetics of this reaction are shown to be in agreement with similar
E Antonini et al.
The Journal of biological chemistry, 258(8), 4676-4678 (1983-04-25)
The formation of the bovine beta-trypsin-bovine basic pancreatic trypsin inhibitor (Kunitz) (BPTI) complex was monitored, making use of three different signals: proflavine displacement, optical density changes in the ultraviolet region, and the loss of the catalytic activity. The rates of
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