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924490

Sigma-Aldrich

Hyaluronic acid methacrylate

Low Viscosity, Low Endotoxin, 0.2 um sterile filtered, 0.2 μm, sterile-filtered

Synonym(s):

HAMA, Hyaluronan, Hyaluronic acid, MeHA

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About This Item

Linear Formula:
(NaC20H28NO15)n
UNSPSC Code:
12352106
NACRES:
NA.23

Quality Level

100

description

Validation : HNMR at 40°C

sterility

sterile-filtered

form

(Solid chunks, fibers or powder)

impurities

≤10 CFU/g Bioburden (Fungal)
≤10 CFU/g Bioburden (Total Aerobic)
100 EU/g Endotoxin

color

white to pale yellow

particle size

0.2 μm

storage temp.

2-8°C

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Application

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid and N-acetyl-D-glucosamine found primarily in connective tissues. HA based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug deliery applications. The methacrylate functionalized hyaluronic acid is photo-crosslinkable, and can be used to generate crosslinked hydrogels.

Packaging

1EA = 500 mg of lyophilized material in glass bottle.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting
Skardal, et al.
Tissue Engineering: Part A, 16 (8) (2010)
Influence of Three-Dimensional Hyaluronic Acid Microenvironments on Mesenchymal Stem Cell Chondrogenesis
Chung and Burdick
Tissue Engineering: Part A, 15(2) (2009)
Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels.
Duan, et al.
Acta Biomaterialia, 9, 7640-7650 (2018)
Micromolding of shape-controlled, harvestable cell-laden hydrogels.
Yeh, et al.
Biomaterials, 27, 5391-5398 (2007)
Judy Yeh et al.
Biomaterials, 27(31), 5391-5398 (2006-07-11)
Encapsulation of mammalian cells within hydrogels has great utility for a variety of applications ranging from tissue engineering to cell-based assays. In this work, we present a technique to encapsulate live cells in three-dimensional (3D) microscale hydrogels (microgels) of controlled
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