Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
303410
Sodium butyrate
98%
Synonym(s):
Butyric acid sodium salt
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About This Item
Recommended Products
Quality Level
Assay
98%
form
powder
mp
250-253 °C (lit.)
SMILES string
[Na+].CCCC([O-])=O
InChI
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChI key
MFBOGIVSZKQAPD-UHFFFAOYSA-M
Gene Information
mouse ... ENSMUSG00000061062(15181)
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General description
Sodium butyrate, an aliphatic sodium salt, serves as an acylating reagent for phenols.[3]
Application
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
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How is shipping temperature determined? And how is it related to the product storage temperature?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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What is the expected solubility in water?
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This product is soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7. 2 (~10 mg/ml).
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Solubility problems with latest batch of sodium butyrate
I had good experience with Sigma's sodium butyrate during the past few years but ran into solubility problems with the latest batch, BCCG8857. The newer batch has some sort of insoluble chemical mixed in with the sodium butyrate - possibly some caking/anti-caking regent?
In the past, I have been able to consistently dissolve 300 mg/mL of sodium butyrate in water or PBS with outstanding results - the solution was perfectly clear and there are no signs of particles. With batch BCCG8857, there are numerous white insoluble particles even when dissolving the sodium butyrate at 60 mg /mL in water. The white insoluble particles tend to adhere near the surface after centrifugation and pellets on the side of the microcentrifuge tube rather than the bottom.
Purchase the smaller sized bottles first to test the lot before making a bigger purchase (I was told there are no other/replacement lots until they go through most of the BCCG8857 lot).
- Received an incentive for this review
- Yes
Recommends this productNoHelpful?
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Thank you for taking the time to leave a review! We are sorry to hear that your experience did not meet expectations. We would like to learn more about your experience to see if there is anything we can do to help troubleshoot this issue. A member from our Technical Service Team will be contacting you shortly. Thank you again for your feedback.
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