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220930

Sigma-Aldrich

Potassium nitrosodisulfonate

Synonym(s):

Dipotassium nitrosodisulfonate, Fremy’s salt

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1 G
€75.40
10 G
€217.00
50 G
€764.00

About This Item

Linear Formula:
(KSO3)2NO
CAS Number:
14293-70-0
Molecular Weight:
268.33
EC Number:
238-219-0
MDL number:
MFCD00010878
UNSPSC Code:
12352000
PubChem Substance ID:
24853200
NACRES:
NA.22
grade:
for analytical purposes
form:
powder

€75.40

Please contact Customer Service for Availability
Request a Bulk Order

grade

for analytical purposes

Quality Level

100

form

powder

reaction suitability

reagent type: oxidant

storage temp.

2-8°C

SMILES string

[K+].[K+].[O]N(S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/2K.H2NO7S2/c;;2-1(9(3,4)5)10(6,7)8/h;;(H,3,4,5)(H,6,7,8)/q2*+1;/p-2

InChI key

IHSLHAZEJBXKMN-UHFFFAOYSA-L

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General description

Potassium nitrosodisulfonate is an oxidizing reagent that can be used to convert phenols, naphthols, and anilines to quinones, benzylic alcohols to aldehydes or ketones, and amino acids to α-keto acids. It can also be used for the preparation of heterocyclic quinones and oxidative aromatization[1].

Application

Potassium nitrosodisulfonate can be used as an oxidizing reagent for the oxidation of:
  • Aromatic amines to their corresponding quinones[2].
  • Hydroethidine to 2-hydroxyethidium[3].
  • Tyrosine to o-quinones[4].

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H260,H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Oral - Water-react 1

Supplementary Hazards

EUH014

Storage Class Code

4.3 - Hazardous materials which set free flammable gases upon contact with water

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX1632
MKCX1631
MKCP7322
MKCN6571
MKCL9549

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F J Hornicek et al.
Chemico-biological interactions, 55(3), 289-302 (1985-11-01)
Nitroxyldisulfonate [Fremy's salt; (KSO3)2NO.] and bisulfite (NaHSO3) have abolished periodic acid (H5IO6)-induced blastogenesis of human peripheral blood lymphocytes (HPBL), but only inhibited the blastogenic response of H5IO6-oxidized rat and mouse lymphocytes, as determined by the rates of nucleic acids synthesis
Potassium Nitrosodisulfonate
Parker K, et al.
e-EROS Encyclopedia of Reagents for Organic Synthesis (2001)
I Islam et al.
Journal of medicinal chemistry, 34(10), 2954-2961 (1991-10-01)
Described herein are structure-activity studies of new antitumor agents based on the pyrrolo[1,2-a]benzimidazole (PBI) ring system. These compounds were designed as new DNA cross-linkers mimicking the mitomycin antitumor agents. Actually, the PBI derivatives were found to have anthracycline-like features: (i)
T P Holler et al.
Biochemistry, 29(7), 1953-1961 (1990-02-20)
Racemic ovothiol A [(+/-)-1a] and the ovothiol model compound 1,5-dimethyl-4-mercaptoimidazole (DMI, 2) were found to scavange the free radicals Fremy's salt (4) and Banfield' radical (5) much more rapidly than did the thiol antioxidant glutathione. Ovothiol A also scavenges the
Vasyl Denysenkov et al.
Physical chemistry chemical physics : PCCP, 12(22), 5786-5790 (2010-05-13)
Dynamic nuclear polarization (DNP) at high magnetic fields (9.2 T, 400 MHz (1)H NMR frequency) requires high microwave power sources to achieve saturation of the EPR transitions. Here we describe the first high-field liquid-state DNP results using a high-power gyrotron
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Oxidizing and Reducing Agents

Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis

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