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162558

Sigma-Aldrich

4-Fluoro-2-nitroaniline

97%

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About This Item

Linear Formula:
FC6H3(NO2)NH2
CAS Number:
364-78-3
Molecular Weight:
156.11
Beilstein:
2210197
EC Number:
206-666-0
MDL number:
MFCD00007830
UNSPSC Code:
12352100
PubChem Substance ID:
24849991
NACRES:
NA.22

Assay

97%

mp

90-94 °C (lit.)

functional group

fluoro
nitro

SMILES string

Nc1ccc(F)cc1[N+]([O-])=O

InChI

1S/C6H5FN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2

InChI key

PUGDHSSOXPHLPT-UHFFFAOYSA-N

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General description

4-Fluoro-2-nitroaniline forms complexes with cobalt(II), nickel(II) and copper(II)[1].

Application

4-Fluoro-2-nitroaniline was used as starting reagent in the synthesis of 4-fluoro-N-ethyl-2-nitroaniline[2] and N-(4-fluoro-2-nitrophenyl)-β-alanine[3].

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

192.2 °F - closed cup

Flash Point(C)

89 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ5149
BCBN3905V
BCBK4043V
BCBC6119V
BCBC6119

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Thomas Hussenether et al.
Bioorganic & medicinal chemistry, 12(10), 2625-2637 (2004-04-28)
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over
Complexes of copper (II), nickel (II) and cobalt (II) with 2-fluoro, 5-nitroaniline and 4-fluoro, 2-nitroaniline.
DeVoto G, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 38(7), 725-728 (1982)
S Singh et al.
The Journal of pharmacology and experimental therapeutics, 296(2), 600-611 (2001-02-13)
The diseases of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by mucus-congested airways. Agents that stimulate the secretion of Cl- are anticipated to facilitate mucociliary clearance and thus be of benefit in the treatment of CF

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