The SPME-LC fiber probes are intended as single-use devices for the extraction of small molecules out of a fluid followed by solvent desorption and LC analysis.
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Journal of chromatography. A, 1217(25), 4041-4060 (2009-12-25)
The primary objective of this review is to discuss recent technological developments in the field of solid-phase microextraction that have enhanced the utility of this sample preparation technique in the field of bioanalysis. These developments include introduction of various new
Journal of pharmaceutical and biomedical analysis, 54(5), 926-950 (2011-01-05)
Biomedical analyses of drugs, metabolites, poisons, environmental and occupational pollutants, disease biomarkers and endogenous substances in body fluids and tissues are important in the development of new drugs, therapeutic monitoring, forensic toxicology, patient diagnosis, and biomonitoring of human exposure to
Metabolic Profiling of Plasma from Cardiac Surgical Patients Concurrently Administered with Tranexamic Acid: DI-SPME?LC?MS Analysis
Bojko, B., et al.
Journal of Pharmaceutical Analysis, 4 (1), 6-13 (2014)
The success of in vivo solid phase microextraction (SPME) depends significantly on the selection of calibration method. Three kinetic in vivo SPME calibration methods are evaluated in this paper: (1) on-fibre standardization (OFS), (2) dominant pre-equilibrium desorption (DPED), and (3)
Journal of chromatography. A, 1216(45), 7664-7669 (2009-09-22)
Solid-phase microextraction (SPME) has been demonstrated to be useful for in vivo sampling in pharmacokinetic studies. In this study, a single time-point kinetic calibration for in vivo dynamic monitoring was developed by simplification of the laborious multiple time-point kinetic calibration
Accurate protein binding affinities were measured using bioSPME more rapidly than membrane dialysis (RED) techniques. Binding affinities correlated to the reference values.
A demonstration of the use of innovative BioSPME fibers for the selective extraction of drugs and polar metbolites from biological matrices.
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