WH0009588M1
Monoclonal Anti-PRDX6 antibody produced in mouse
clone 3A10-2A11, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-1Cys, Anti-AOP2, Anti-KIAA0106, Anti-MGC46173, Anti-NSGPx, Anti-PRX, Anti-aiPLA2, Anti-p29, Anti-peroxiredoxin 6
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All Photos(4)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3A10-2A11, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRDX6(9588)
General description
Peroxiredoxin 6 (Prdx6) is a non-seleno peroxidase enzyme, encoded by the gene mapped to human chromosome 1q25.1. Prdx6 belongs to thiol-specific antioxidant protein family. It is highly expressed in lung, alveolar epithelial type II cells and alveolar macrophages. The protein is characterized with a single conserved cysteine residue and is called 1-Cys Prdx. Prdx6 contains 224 amino acids.
Immunogen
PRDX6 (AAH35857.1, 1 a.a. ~ 224 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
Sequence
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
Biochem/physiol Actions
Peroxiredoxin 6 (Prdx6) is a bifunctional enzyme, carrying out both phospholipase A2 (PLA2) activity and glutathione (GSH) peroxidase function. The encoded protein aids in redox regulation of the cell and is implicated in reduction of H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. It might also have a crucial role in the regulation of phospholipid turnover and in antioxidant defense. Prdx6 is highly expressed at leading edges of wounds and aids in wound healing. Deficiency of the enzyme activity is observed in cataracts of the lens. Overexpression of Prdx6 leads to several degenerative CNS (central nervous system) disorders such as Alzheimer′s, Parkinson′s, Pick′s, and Crutzfeld-Jakob diseases and schizophrenia. In addition, elevated expression of the enzyme is also observed in various neoplastic diseases including malignant mesothelioma, bronchogenic squamous cell carcinoma and cancer of the gingivo-buccal area, bladder and breast.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Daniel Martins-de-Souza et al.
BMC psychiatry, 9, 17-17 (2009-05-02)
Schizophrenia is likely to be a consequence of DNA alterations that, together with environmental factors, will lead to protein expression differences and the ultimate establishment of the illness. The superior temporal gyrus is implicated in schizophrenia and executes functions such
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.
Matins-de-Souza, et.al
BMC Psychiatry, 9, 17-17 (2009)
Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
Fisher AB
Antioxidants & Redox Signaling, 15(3) , 831-844 (2011)
Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress.
Wang Y
Journal of Cellular Biochemistry, 104(4) , 1274-1285 (2008)
Rimpy Kaur Chowhan et al.
Scientific reports, 10(1), 17416-17416 (2020-10-17)
Peroxiredoxin 6 (Prdx6) is a ubiquitously expressed antioxidant non-selenium glutathione peroxidase that is known to play a major role in various physiological and pathological processes. It belongs to the family of peroxidases (referred to as Peroxiredoxins, Prdx's) that work independently
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