Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.
Immunogen
Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.
Biochem/physiol Actions
Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca2+ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.
Physical form
Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
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International journal of molecular medicine, 49(2) (2021-12-23)
Persistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high clinical mortality rate and a poor prognosis. At present, the treatment of PPHN is based mainly
Intracellular accumulating of the hyperphosphorylated tau plays a pivotal role in neurodegeneration of Alzheimer disease (AD), but the mechanisms underlying the gradually aggravated tau hyperphosphorylation remain elusive. Here, we show that increasing intracellular tau could upregulate mRNA and protein levels
The Role of Transient Receptor Potential Cation Channel, Subfamily C, Member 1 in the Odontoblast-like Differentiation of Human Dental Pulp Cells
Song Z
Journal of Endodontics, 43, 315-320 (2017)
Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing
Selli C
Molecular and Cellular Biochemistry, 420, 129-140 (2016)
Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
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