SML3777

SAR7334

≥98% (HPLC)

• Synonym(s): SAR-7334, 4-({(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)-3-chlorobenzonitrile, 4-[rac-trans-(1,2)-2-((R)-3-Aminopiperidin-1-yl)indan-1-yloxy]-3-chlorobenzonitrile, SAR 7334
• Empirical Formula (Hill Notation): C₂₁H₂₂ClN₃O
• CAS Number: 1333210-07-3
• Molecular Weight: 367.87
• MDL number: MFCD27992059
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N
• InChI key: RLKRLNQEXBPQGQ-OZOXKJRCSA-N

Description

Biochem/physiol Actions

TRPC6-selective transient receptor potential channel (TRPC) inhibitor.



SAR7334 is a TRPC6-selective transient receptor potential channel (TRPC) inhibitor (IC50 against OAG-induced Ca2+ influx in TRPC3/6/7-expressing cells = 9.5/226/282 nM, IC50 >10 μM in TRPC4/10 cells; IC50 = 7.9 nM by whole-cell patch-clamp using TRPC6-HEK-FITR cells).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable