SML3243
NA-11
≥98% (HPLC)
Synonym(s):
N-(2-(2-(5-hydroxypent-1-yn-1-yl)phenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
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About This Item
Empirical Formula (Hill Notation):
C24H23N3O3
Molecular Weight:
401.46
UNSPSC Code:
12352107
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OCCCC#CC1=CC=CC=C1C2=NN3C(COC(C=C(NC(C)=O)C=C4)=C4C3)=C2
Biochem/physiol Actions
NA-11 is a potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst and neutrophil cell death (NETosis). NA-11 decreases neutrophiles efficiency to kill bacteria. It prevents neutrophil-induced tissue damage.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Neri Amara et al.
Cell, 184(17), 4480-4494 (2021-07-29)
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens. However, excessive NOX2 activity can exacerbate inflammation, as in acute respiratory distress syndrome (ARDS).
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