SML0624

PE 154

≥97% (HPLC)

• Synonym(s): 2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid
• Empirical Formula (Hill Notation): C₃₅H₃₅N₅O₄
• CAS Number: 1192750-33-6
• Molecular Weight: 589.68
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥97% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• InChI: 1S/C35H35N5O4/c1-3-40(4-2)24-17-18-27-31(20-24)44-35(43)28(34(27)42)21-36-23-15-13-22(14-16-23)19-32(41)38-39-33-25-9-5-7-11-29(25)37-30-12-8-6-10-26(30)33/h5,7,9,11,13-18,20-21,36H,3-4,6,8,10,12,19H2,1-2H3,(H,37,39)(H,38,41)/b28-21+
• InChI key: CYZIIGRHLSZNAV-SGWCAAJKSA-N

Description

Biochem/physiol Actions

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to associate with β-amyloid plaques, and histological co-localization of AChE and Ab peptides is well established in Alzheimer′s disease. PE-154 is a fluorescent inhibitor of both AChE and BChE with IC₅₀ values of 280 pM and 16 nM. PE-154 stains Aβ plaques in both rodent and human tissue samples, and does not cross react with phospho-tau.

PE 154 is a fluorescent acetylcholinesterase inhibitor.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable