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SMB00607

Sigma-Aldrich

Amoxicillin trihydrate: potassium clavulanate (4:1)

Synonym(s):

Amoxicillin Trihydrate: Potassium Clavulanate

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About This Item

UNSPSC Code:
51285005
NACRES:
NA.85
Pricing and availability is not currently available.

form

powder

Quality Level

200

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

color

white to yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

General description

Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.[1]

Application

Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.[2]

Biochem/physiol Actions

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.[3][4] Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases[5] found in bacteria that are resistant to penicillins and cephalosporins.[6]

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.[7]

Packaging

1G

Components

Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.

Storage and Stability

Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

Pictograms

FlameHealth hazard
GHS02,GHS08

Signal Word

Danger

Hazard Statements

H228,H252,H317,H334

Hazard Classifications

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

Supplementary Hazards

EUH014,EUH044

Storage Class Code

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000410521
0000410521
0000368640
0000368640
0000174275

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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
A P Ball et al.
Lancet (London, England), 1(8169), 620-623 (1980-03-22)
Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and
R N Brogden et al.
Drugs, 18(3), 169-184 (1979-09-01)
Amoxycillin, an acid stable semisynthetic penicillin shown to be effective against a wide range of infections when given orally, is now available for intramuscular and intravenous injection. Amoxycillin has an antibacterial spectrum and level of activity essentially the same as
Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
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Questions

  1. What are the uses and potential reactions of Amoxicillin and Clavulanate Potassium

    1 answer

    1. This product is supplied for research purposes with the primary use as an antibiotic. Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin's antibacterial activity against bacteria normally resistant to β-lactam antibiotics. Please see the peer-reviewed paper section in the link below for potential use information.

      https://www.sigmaaldrich.com/search/smb00607?focus=papers&page=1&perpage=30&sort=relevance&term=SMB00607&type=citation_search

      Products are not tested for safety and efficacy in food, drug, medical device, cosmetic, commercial, or any other use. Potential reactions or side effects are not evaluated.

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