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SAB4501583

Sigma-Aldrich

Anti-Integrin β1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CD29, FNRB, Fibronectin receptor β subunit, ITB1, Integrin VLA-4 β subunit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 88 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

P05556

UniProt accession no.

P05556

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ITGB1(3688)

General description

Anti-Integrin β1 Antibody detects endogenous levels of total Integrin β1 protein.
Integrin β1 is a mechanosensor, that is located on human chromosome 10p11.22. It is present in normal cells and tumor-associated cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human Integrin beta1.

Immunogen Range: 746-795

Application

Anti-Integrin β1 antibody has been used in western blotting.

Biochem/physiol Actions

Integrin β1 acts as an adhesive molecule in the development of de novo focal contact, keratinocyte migration and re-epithelialization of wound tissue.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer.
Yin HL, et al.
International Journal of Molecular Sciences, 17(9) (2016)
Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage.
Liu L,et al.
The American Journal of Pathology, 187(11), 2508-2519 (2017)
Genomic aberrations associated with erlotinib resistance in non-small cell lung cancer cells.
Serizawa M, et al.
Anticancer Research, 33(12), 5223-5233 (2013)
β1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model.
Lu D, et al.
BioMedical Engineering OnLine, 15(2), 130-130 (2016)
Lingyun Liu et al.
The American journal of pathology, 187(11), 2508-2519 (2017-08-22)
Gametogenetin binding protein 2 (GGNBP2) is an evolutionarily conserved zinc finger protein. Although Ggnbp2-null embryos in the B6 background died because of a defective placenta, 6.8% of Ggnbp2-null mice in the B6/129 mixed background were viable and continued to adulthood.

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