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S3066

Sigma-Aldrich

SKF-89626 hydrobromide

>98% (HPLC), solid

Synonym(s):

4-(3,4-Dihydroxyphenyl)-4,5,6,7-tetrahydro­thieno[2,3-c]pyridine

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About This Item

Empirical Formula (Hill Notation):
C13H13NO2S · HBr
Molecular Weight:
328.22
MDL number:
MFCD04040024
UNSPSC Code:
12352200
PubChem Substance ID:
24278702
Pricing and availability is not currently available.

Assay

>98% (HPLC)

form

solid

color

white

solubility

H2O: soluble 11 mg/mL

SMILES string

Br[H].Oc1ccc(cc1O)C2CNCc3sccc23

InChI

1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H

InChI key

QAIGGSDECIJPNW-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.

Biochem/physiol Actions

D1 dopamine receptor agonist.
SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.[1][2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
032K4707

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E B Nielsen et al.
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds

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