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R9157

Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Synonym(s):

2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

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About This Item

Empirical Formula (Hill Notation):
C21H33NO3
CAS Number:
303-75-3
Molecular Weight:
347.49
MDL number:
MFCD01663028
UNSPSC Code:
12352200
PubChem Substance ID:
329824045

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: 16 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C

InChI

1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3

InChI key

TUNMGCULOKMBNJ-UHFFFAOYSA-N

Biochem/physiol Actions

Ro 4-1284 is a reversible VMAT2 inhibitor.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H400

Precautionary Statements

P273

Hazard Classifications

Aquatic Acute 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
089K4610

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G Karakiulakis et al.
Journal of cellular biochemistry, 52(1), 92-106 (1993-05-01)
Type IV collagen-degrading activity was expressed in homogenates of Lytechinus pictus embryos during embryogenesis. Activity was concentrated 1,600-fold by ammonium sulfate fractionation, ion exchange, and gel chromatography and could not be activated further upon trypsin or organomercurial treatment. This enzyme
E Schömig et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(2), 160-170 (1990-08-01)
After loading of the incubated rat vas deferens with 0.2 mumol/l 3H-noradrenaline (followed by 100 min of wash-out with amine-free solution), the efflux of endogenous and exogenous compounds was determined by HPLC with electrochemical detection and by column chromatography with
G C Haralabopoulos et al.
Laboratory investigation; a journal of technical methods and pathology, 71(4), 575-582 (1994-10-01)
The formation of a basement membrane is the last step in the development of a new blood vessel. Matrigel, a laminin-rich reconstituted basement membrane matrix induces the differentiation of endothelial cells into capillary-like structures. The effect of inhibitors of basement
D R Bull et al.
Neuroscience letters, 134(1), 41-44 (1991-12-16)
The present study has employed the technique of fast cyclic voltammetry to measure electrically-evoked dopamine release within the central amygdaloid complex in a rat brain slice. Local electrical stimulation caused the release of an electroactive substance which was identified, biochemically
G A Marks et al.
Brain research, 815(1), 21-28 (1999-02-12)
Ponto-geniculo-occipital (PGO) waves are spontaneously occurring field potentials recorded in the dorsal lateral geniculate nucleus (LGN) just prior to and during rapid eye movement (REM) sleep. Facilitated discharge rates of LGN neurons are associated with PGO waves. In kittens during
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