P8749

Psammaplin A

≥97% (HPLC), solid

• Synonym(s): Bisprasin, N,N"-(dithiodi-2,1-ethanediyl)bis[3-bromo-4-hydroxy-a-(hydroxyimino)-benzenepropanamide
• Empirical Formula (Hill Notation): C₂₂H₂₄Br₂N₄O₆S₂
• CAS Number: 110659-91-1
• Molecular Weight: 664.39
• UNSPSC Code: 12352200

Properties

• Assay: ≥97% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O\N=C(\Cc1ccc(O)c(Br)c1)C(=O)NCCSSCCNC(=O)C(\Cc2ccc(O)c(Br)c2)=N/O

Description

Biochem/physiol Actions

Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase inhibitor.

Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Psammaplin A impedes angiogenesis as well as bacterial and tumor cell growth. Psammaplin A inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves