O6503

L-Ornithine monohydrochloride

BioReagent, suitable for cell culture, ≥99%

• Synonym(s): (S)-2,5-Diaminopentanoic acid monohydrochloride
• Empirical Formula (Hill Notation): C₅H₁₂N₂O₂ · HCl
• CAS Number: 3184-13-2
• Molecular Weight: 168.62
• Beilstein: 3625847
• EC Number: 221-678-6
• MDL number: MFCD00064562
• UNSPSC Code: 12352209
• PubChem Substance ID: 24898036
• NACRES: NA.75

Properties

• biological source: microbial
• product line: BioReagent
• Assay: ≥99%
• form: powder
• packaging: pkg of 100 g; pkg of 25 g
• technique(s): cell culture | mammalian: suitable
• impurities: ammonia and citrulline, essentially free
• solubility: H₂O: soluble 50 mg/mL, clear, colorless to very faintly yellow
• SMILES string: Cl.NCCC[C@H](N)C(O)=O
• InChI: 1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• InChI key: GGTYBZJRPHEQDG-WCCKRBBISA-N

Description

General description

L-Ornithine is the functional metabolite of L-arginine.

L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Application

L-Ornithine monohydrochloride has been used:

• as a supplement in Dulbecco′s modified eagle medium (DMEM) for cell growth assays
• as a component in the standard medium for primary human hepatocytes (PHH) culture
• as a creatine synthesis inhibitor

Biochem/physiol Actions

L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain.

L-Ornithine is used as a media supplement to support the biosynthesis of polyamines.

Other Notes

Product of arginine degradation by arginase

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves