NOTCH homolog-2 (NOTCH2) is part of the NOTCH signaling pathway and the gene encoding it is localized on chromosome 1p13-p11.
Immunogen
synthetic peptide corresponding to residues 1718-1733 of human NOTCH2. This sequence is 93% identical in mouse and rat.
Biochem/physiol Actions
NOTCH homolog-2 (NOTCH2) is a stimulator of metaplasia in goblet cells, which is seen in respiratory diseases like asthma. Mutations in the NOTCH2 gene are associated with Hajdu-Cheney syndrome.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
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The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus. In the conducting airway, basal cells act
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a
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