Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

L6135

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

biotin conjugate, lyophilized powder

Synonym(s):

PNA, Peanut agglutinin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.

conjugate

biotin conjugate

Quality Level

200

form

lyophilized powder

mol wt

120 kDa

composition

Protein, ≥80% Lowry

extent of labeling

~3 mol biotin per mol protein

technique(s)

blood typing: suitable
fractionation: suitable

solubility

water: 1.00-1.10 mg/mL, clear to slightly hazy, colorless

storage temp.

2-8°C

Looking for similar products? Visit Product Comparison Guide

General description

Peanut lectin (PNA) is a lectin or an agglutinin from the legume, Arachis hypogaea,[1] found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3) N-acetylgalactosamine.[1]

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • in enzyme-linked micro plate assay to detect β-D-galactose-N-acetylglucosamine[2]
  • in Immunohistochemical double staining[3]
  • Immunohistochemical double staining for the detection of germinal centers[4]
  • in enzyme-linked microplate assayto detect β-D-galactose-N-acetylglucosamine[2]

Biochem/physiol Actions

Lectin from Arachis hypogaea (peanut) functions as an antigenic determinant for Thomsen-Friedenreich antigen (TF)[5] and as mitogen for colorectal cancer stimulation cell division in normal colonic epithelium.[6] It is therefore used as tumor marker.[7]
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Packaging

Package size based on protein content.

Physical form

Contains sodium citrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000318522
0000316089
059M4186V
11190165

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

In situ observation of germinal center cell apoptosis during a secondary immune response
Saitoh HA, et al.
Journal of Clinical and Experimental Hematopathology : JCEH, 46, 73-82 (2006)
Peanut (Arachis hypogaea) lectin recognizes α−linked galactose, but not N-acetyl lactosamine in N-linked oligosaccharide terminals
Chacko BK and Appukuttan PS
International Journal of Biological Macromolecules, 28, 365-371 (2001)
Synthesis of glycopolymers and their multivalent recognitions with lectins
Ting SRS, et al.
Polym. Chem., 1, 1392-1412 (2010)
Inhibition of influenza viral neuraminidase activity by collectins
Tecle T, et al.
Archives of Virology, 1731-1742 (2007)
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus--infected mice
GeurtsvanKessel CH, et al.
The Journal of Experimental Medicine, 206, 2339-2349 (2009)
View All Related Papers

Questions

1–3 of 3 Questions  

  1. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  2. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  3. Is the peanut lectin (Lectin from Arachis hypogaea) a glycoprotein?  If so, what is the carbohydrate content?

    1 answer

    1. Peanut lectin is not a glycoprotein. Although peanut lectin binds specifically to a particular carbohydrate (beta-gal(1-->3)galNac) in other molecules, the lectin itself does not contain any carbohydrate.  Please see page 231 of the following paper: R. Banerjee, et al., "Crystal structure of peanut lectin, a protein with an unusual quaternary structure".  Proc. Nat. Acad. Sci., USA, 91, 227-231 (1994).

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service