L5408
LY-171,883
≥98% (TLC)
Synonym(s):
5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole, Tomelukast
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C16H22N4O3
CAS Number:
Molecular Weight:
318.37
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
SMILES string
CCCc1c(O)c(ccc1OCCCCc2nnn[nH]2)C(C)=O
InChI
1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChI key
MWYHLEQJTQJHSS-UHFFFAOYSA-N
Biochem/physiol Actions
Selective leukotriene D4 (LTD4) receptor antagonist; PPARα and PPARγ agonist.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
N L Anderson et al.
Toxicology and applied pharmacology, 137(1), 75-89 (1996-03-01)
We have investigated the effects of five peroxisome proliferators (PPs : clofibric acid, DEHP, WY14,643, nafenopin, and LY171883) on the abundances of a large number of proteins in the livers of treated mice at 5- and 35-day time points. LY171883
Ingalill Avis et al.
Cancer research, 65(10), 4181-4190 (2005-05-19)
Arachidonic acid (AA) metabolizing enzymes and peroxisome proliferator-activated receptors (PPARs) have been shown to regulate the growth of epithelial cells. We have previously reported that exposure to the 5-lipoxygenase activating protein-directed inhibitor MK886 but not the cyclooxygenase inhibitor, indomethacin, reduced
K Yamakawa et al.
Biochemical and biophysical research communications, 271(3), 571-574 (2000-05-18)
Vascular endothelial growth factor (VEGF), expressed in a variety of mesenchymal cells including vascular smooth muscle cells (VSMC), is a potent mitogen for endothelial cells, and is used clinically applied for ischemic disease of peripheral vessels. To determine whether peroxisome
Furosemide attenuates bronchial responsiveness to antigen challenge "in vitro".
G Folco et al.
Advances in prostaglandin, thromboxane, and leukotriene research, 23, 365-367 (1995-01-01)
T S Rao et al.
The Journal of pharmacology and experimental therapeutics, 269(3), 917-925 (1994-06-01)
Intraperitoneal administration of zymosan to mice resulted in marked biosynthesis of eicosanoids and influx of neutrophils with distinct time course profiles. 6-Keto-prostaglandin-F1 alpha (6-KPA) increased between 30 and 60 min and rapidly decreased thereafter. Leukotriene (LT)C4 levels showed similar patterns
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service