Immunogen Sequence: GI # 53988378, sequence 361-580
Recombinant mesothelin isoform 1 preproprotein
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Molecular cancer therapeutics, 13(11), 2653-2661 (2014-09-23)
The RG7787 mesothelin-targeted recombinant immunotoxin (RIT) consists of an antibody fragment targeting mesothelin (MSLN) fused to a 24-kD fragment of Pseudomonas exotoxin A for cell killing. Compared with prior RITs, RG7787 has improved properties for clinical development including decreased nonspecific
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