C7866

CGP-53353

solid

• Synonym(s): 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2
• Empirical Formula (Hill Notation): C₂₀H₁₃F₂N₃O₂
• CAS Number: 145915-60-2
• Molecular Weight: 365.33
• MDL number: MFCD00938569
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892990
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥98% (HPLC)
• form: solid
• color: orange
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1
• InChI: 1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)
• InChI key: RONQPWQYDRPRGG-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956)

Description

Biochem/physiol Actions

Selective PKCβII inhibitor. IC₅₀ - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC₅₀ of greater than 50 μM.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves