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COO/COA

C4285

Acetyl-Calpastatin (184-210) human

Name: Acetyl-Calpastatin (184-210) human
Brand: SIGMA

~95% (HPLC), powder

Synonym(s):

Acetyl-Calpain inhibitor fragment 184-210, CS peptide

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About This Item

Empirical Formula (Hill Notation):

C₁₄₂H₂₃₀N₃₆O₄₄S

CAS Number:

79079-11-1

Molecular Weight:

3177.63

MDL number:

MFCD01318818

UNSPSC Code:

12352200

Assay

~95% (HPLC)

form

powder

solubility

H₂O: 1 mg/mL

UniProt accession no.

P20810

storage temp.

−20°C

Gene Information

human ... CAST(831)

Amino Acid Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂

Biochem/physiol Actions

Inhibitor of calpain which induces an increase in secreted amyloid β-protein 1-42.

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Obesity-associated dysregulation of calpastatin and MMP-15 in adipose-derived stromal cells results in their enhanced invasion.

Amy L Strong et al.

Stem cells (Dayton, Ohio), 30(12), 2774-2783 (2012-09-13)

Adipose tissue maintains a subpopulation of cells, referred to as adipose-derived stromal/stem cells (ASCs), which have been associated with increased breast cancer tumorigenesis and metastasis. For ASCs to affect breast cancer cells, it is necessary to delineate how they mobilize

Inhibition of myelin-cleaving poteolytic activities by interferon-beta in rat astrocyte cultures. Comparative analysis between gelatinases and calpain-II.

Tiziana Latronico et al.

PloS one, 8(2), e49656-e49656 (2013-02-08)

Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and

Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution.

Samuele De Minicis et al.

Liver international : official journal of the International Association for the Study of the Liver, 32(10), 1574-1584 (2012-09-04)

Survival of hepatic stellate cells (HSCs) is a hallmark of liver fibrosis, while the induction of HSC apoptosis may induce recovery. Activated HSC are resistant to many pro-apoptotic stimuli. To this issue, the role of Endoplasmic Reticulum (ER) stress in

Single nucleotide polymorphisms in caprine calpastatin gene.

R Sharma et al.

Genetika, 49(4), 505-512 (2013-07-23)

The calpains and calpastatin (CAST) make up a major cytosolic proteolytic system, the calpain-calpastatin system, found in mammalian tissues. The relative levels of the components of the calpain-calpastatin system determine the extent of meat tenderization during postmortem storage. Calpastatin (CAST)

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Hyunil Jo et al.

Journal of the American Chemical Society, 134(42), 17704-17713 (2012-09-25)

We have designed a highly specific inhibitor of calpain by mimicking a natural protein-protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this goal we established a new method of stabilizing an α-helix in a small peptide by

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