EGF-like-domain, multiple 8 (EGFL8), an EGFL7 paralog, is downregulated in metastatic colorectal cancers (CRC) making it a potential prognostic marker for poor prognosis in CRC and advanced gastric cancer.
Specificity
Anti-EGFL8 polyclonal antibody reacts with pig, bovine, human, mouse, and rat EGF-like-domain, multiple 8 proteins.
Immunogen
Synthetic peptide directed towards the C terminal region of human EGFL8
Application
Anti-EGFL8 polyclonal antibody is used to tag EGF-like-domain, multiple 8 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of EGF-like-domain, multiple 8 protein as a potential prognostic marker for gastrointestinal cancers such as gastric cancer and colorectal cancer.
Sequence
Synthetic peptide located within the following region: QAGAWVRAVLPVPPEELQPEQVAELWGRGDRIESLSDQVLLLEERLGACS
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
International journal of molecular medicine, 36(2), 541-550 (2015-06-23)
Epidermal growth factor (EGF)-like (EGFL) domain, a common structural module in numerous secreted or transmembrane proteins, is generally involved in protein-protein interactions. To date, several EGFL proteins have been identified and characterized, but little is known about EGFL domain 8
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