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80714

Supelco

Tanshinone I

analytical standard

Synonym(s):

Tanshinon I, Tanshinone A, Tanshinquinone I

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About This Item

Empirical Formula (Hill Notation):
C18H12O3
CAS Number:
568-73-0
Molecular Weight:
276.29
MDL number:
MFCD00210563
UNSPSC Code:
85151701
PubChem Substance ID:
329769042
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12

InChI

1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

InChI key

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

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General description

Tanshinone I is a bioconstituent, belonging to the class of tanshinone compounds isolated from Salvia miltiorrhiza Bunge. It is commonly used to dilate coronary arteries, increase coronary flow, modulate mutagenic activity and protect the myocardium against ischaemia.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tanshinone I may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and roots of Salvia miltiorrhiza using different chromatography techniques.

Biochem/physiol Actions

Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules. Anti-inflammatory.
Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules.Anti-inflammatory.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF0983
BCBZ6746
BCBX3959
BCBS1432V

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Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn
Liu H-A, et al.
Journal of Chromatography. B, Biomedical Applications, 846(1-2), 32-41 (2007)
Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC
Shi Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(3), 481-486 (2005)
Xiao-Hong Tian et al.
Expert opinion on therapeutic patents, 23(1), 19-29 (2012-10-26)
Tanshinone IIA (TSIIA), cryptotanshinone and tanshinone I are major bioactive constituents of Danshen, a Chinese herbal medicine. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of TSIIA and it is currently used for treating cardiovascular diseases in China. The
Xin Liu et al.
Biomaterials, 34(3), 817-830 (2012-11-01)
Tanshinone IIA is a good candidate for treating cerebral ischemia, but its short half-life and poor permeability across the blood-brain-barrier (BBB) limit its curative efficacy. In this study, we successfully developed cationic bovine serum albumin-conjugated tanshinone IIA PEGylated nanoparticles (CBSA-PEG-TIIA-NPs).
Irina Tsoy Nizamutdinova et al.
International immunopharmacology, 14(4), 650-657 (2012-10-23)
The goal of this study was to investigate the differential effect of tanshinone IIA on the induction of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by TNF-α and the possible molecular mechanisms by which it regulates ICAM-1
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