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Supelco

Rhein

analytical standard

Synonym(s):

4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow

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About This Item

Empirical Formula (Hill Notation):
C15H8O6
CAS Number:
Molecular Weight:
284.22
Beilstein:
2222155
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤5.0% water

mp

≥300 °C (lit.)

application(s)

food and beverages

format

neat

SMILES string

OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

InChI key

FCDLCPWAQCPTKC-UHFFFAOYSA-N

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General description

Rhein is an active component of rhubarb (Rheum officinale), a medicinal herb in traditional Chinese medicine (TCM). It is known to exhibit antibacterial and anti-inflammatory activities.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Rhein may be used as an analytical reference standard for the determination of the analyte in rat plasma and rhubarb roots, dock flowers and senna leaves by column-switching high-performance liquid chromatography and normal-phase high performance liquid chromatography, respectively.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2


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Certificates of Analysis (COA)

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Determination of anthraquinones in rhubarb roots, dock flowers and senna leaves by normal-phase high performance liquid chromatography.
Djozan DJ and Assadi Y
Talanta, 42(6), 861-865 (1995)
Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.
Yi L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 838(1), 50-55 (2006)
Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Zhao YL, et al.
Food And Chemical Toxicology, 49(8), 1705-1710 (2011)
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, et al.
Kidney International, 91(1), 144-156 (2017)
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with

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