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MABT63

Sigma-Aldrich

Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4

clone N3.12.4, from mouse

Synonym(s):

poliovirus receptor-related 3, poliovirus receptor-related protein 3, nectin 3, nectin-3, Nectin-3, CD113 antigen

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N3.12.4, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG2aκ

NCBI accession no.

NP_056295

UniProt accession no.

Q9NQS3

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... NECTIN3(25945)

General description

Nectin-3, also known as Poliovirus receptor-related protein 3 (PVRL3) and PRR3, is thought to work with cadherin to form cell-cell adherens junctions. It is a transmembrane protein that is commonly found in the testis and in placental tissue. Nectin-3 colocalizes with CD155, the cognate receptor for poliovirus, to cell-cell junctions. Nectin-3′s involvement in down-regulation PVR from the cell surface leads to a reduction in cell motility and proliferation.

Immunogen

Full length recombinant protein corresponding to human Nectin-3.

Application

Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 detects level of Nectin-3/PVRL3 (CD113) & has been published & validated for use in FC.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Quality

Evaluated by Flow Cytometry in U251 cells.

Flow Cytometry Analysis: 0.1 µg of this antibody detected Nectin-3 in U251 cells.

Target description

61 kDa calculated

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
U251 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dario Gerace et al.
Cell reports. Medicine, 4(1), 100879-100879 (2023-01-05)
Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches to produce immune-evasive SC-islet cells have so far shown variable results. Here, we show that targeting human

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