AB3500P
Anti-Anion Exchanger 1 Antibody
Chemicon®, from rabbit
Synonym(s):
AE1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
rat ... Slc4A1(24779)
Specificity
Recognizes rat Anion Exchanger 1 (AE1). The immunogen shows no significant sequence homology with other AE or other proteins.
SPECIES REACTIVITIES: The immunogen sequence is 90% conserved in mouse, 75% in human and 70% in bovine. Reactivity with other species has not been confirmed.
SPECIES REACTIVITIES: The immunogen sequence is 90% conserved in mouse, 75% in human and 70% in bovine. Reactivity with other species has not been confirmed.
Immunogen
A 20 amino acid peptide sequence near the N-terminus of rat AE1 (Kudrycki et al. 1989; Kopito et al. 1985; Raida et al. 1989; Lux et al. 1989; Tanner et al. 1988).
Application
Anti-Anion Exchanger 1 Antibody detects level of Anion Exchanger 1 & has been published & validated for use in ELISA & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western blot: 1-10 μg/mL using ECL. AE1 has a molecular weight of approximately 90-100 kDa. It aggregates easily forming dimers and multimers. It may also be proteolytically processed to smaller fragments of 60, 40 and 20 kDa.
ELISA: 1-10 μg/mL using 1 μg/mL control peptide per well.
Optimal working dilutions must be determined by the end user.
ELISA: 1-10 μg/mL using 1 μg/mL control peptide per well.
Optimal working dilutions must be determined by the end user.
Physical form
Affinity purified immunoglobulin. Liquid in Liquid in PBS with 0.1% BSA.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Xuming Sun et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 21(1-3), 95-108 (2008-01-23)
Intercalated cells (ICs) of the kidney collecting duct are rich in carbonic anhydrase II (CAII), which facilitates proton and bicarbonate transport. Bicarbonate secretion is mediated via Pendrin (Slc26a4), which is expressed on the apical membrane of B-ICs and nonA-nonB ICs
Nicole Gröger et al.
Human molecular genetics, 21(5), 1025-1036 (2011-11-16)
The human SLC4A5 gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status. The biochemical basis of this association is unknown particularly since no single
Sekiya Shibazaki et al.
Human molecular genetics, 17(11), 1505-1516 (2008-02-12)
Polycystic kidney disease (ADPKD) results from failure of the kidney to properly maintain three-dimensional structure after loss of either polycystin-1 or -2. Mice with kidney selective inactivation of Pkd1 during embryogenesis develop profound renal cystic disease and die from renal
Xuming Sun et al.
American journal of physiology. Renal physiology, 309(2), F120-F136 (2015-05-15)
We previously reported that the deletion of the pH sensor GPR4 causes a non-gap metabolic acidosis and defective net acid excretion (NAE) in the GPR4 knockout mouse (GPR4-/-) (Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB
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