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AB1258

Sigma-Aldrich

Anti-Cytochrome P450 Enzyme CYP1A1 Antibody

serum, Chemicon®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_000499.2

UniProt accession no.

P04798

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... AHRR(57491)

Specificity

Reacts with human cytochrome P450 CYP1A1 in human placental microsomal fraction and to recombinant human CYP1A1.

Immunogen

Synthetic peptide

Application

Anti-Cytochrome P450 Enzyme CYP1A1 Antibody detects level of Cytochrome P450 Enzyme CYP1A1 & has been published & validated for use in IH & WB.
Research Category
Metabolism
Research Sub Category
Enzymes & Biochemistry
Western blot

Immunohistochemistry

Optimal working dilutions must be determined by end user.

Linkage

Replaces: MAB3522

Physical form

Rabbit antiserum. Liquid, no preservatives.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Kapelyukh et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(8), 907-918 (2019-05-31)
Cytochrome P450s CYP1A1 and CYP1A2 can metabolize a broad range of foreign compounds and drugs. However, these enzymes have significantly overlapping substrate specificities. To establish their relative contribution to drug metabolism in vivo, we used a combination of mice humanized
Xiao-Fei Yin et al.
Oncology reports, 30(1), 364-370 (2013-04-23)
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with tumor initiation and progression. AhR expression is significantly increased in gastric cancer tissues and gastric cancer cell lines; however, the relationship between AhR and gastric cancer is still unclear.
De Lin et al.
The Journal of pharmacology and experimental therapeutics, 363(1), 12-19 (2017-09-09)
Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side effects including vascular occlusions, pancreatitis, and liver toxicity, although the underlying mechanisms remain unclear. Modifications of critical proteins through reactive metabolites are thought
Tie-Li Peng et al.
World journal of gastroenterology, 15(14), 1719-1729 (2009-04-11)
To determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment. RT-PCR, real-time PCR, and Western blotting were performed to detect AhR expression in 39
Xiao-Fei Yin et al.
Journal of experimental & clinical cancer research : CR, 31, 46-46 (2012-05-18)
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was to detect the effects of DIM on gastric cancer cell growth. Gastric cancer cell SGC7901
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