516566

PPARγ Antagonist III, G3335

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

• Synonym(s): PPARγ Antagonist III, G3335, H-Trp-Glu-OH
• Empirical Formula (Hill Notation): C₁₆H₁₉N₃O₅
• CAS Number: 36099-95-3
• Molecular Weight: 333.34
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 30 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
• InChI key: PWIQCLSQVQBOQV-AAEUAGOBSA-N

Description

General description

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PPARγ

Product does not compete with ATP.

Reversible: yes

kd = ~ 8 µM as PPARγ antagonist

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Addition of a small amount of acid or base may be required for complete solubilization.

Reconstitution

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ye, F., et al. 2006. Chembiochem7, 74.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable