428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem^®

• Synonym(s): Latrunculin B, Latrunculia magnifica
• Empirical Formula (Hill Notation): C₂₀H₂₉NO₅S
• CAS Number: 76343-94-7
• Molecular Weight: 395.51
• MDL number: MFCD00270879
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.
• Quality Level: 100
• description: Merck USA index - 14, 5378
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white to yellow
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• InChI key: NSHPHXHGRHSMIK-JRIKCGFMSA-N

Description

General description

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable