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860837P

Avanti

CER7-2′R,6R(d9)

Avanti Research™ - A Croda Brand 860837P, powder

Synonym(s):

N(2′-(R)-hydroxypalmitoyl(d9)) 6R-hydroxysphingosine

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About This Item

Empirical Formula (Hill Notation):
C34H58D9NO5
CAS Number:
2260670-24-2
Molecular Weight:
578.95
UNSPSC Code:
12352100
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860837P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860837P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCC[C@@H](O)/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O)CO

General description

6-Hydroxysphingosine is one of the moieties that make up the class of ceramides, which are lipids localized to stratum corneum. It is formed due to incorporation of hydroxyl group to long chain bases.

Application

N(2′-(R)-hydroxypalmitoyl(d9)) 6R-hydroxysphingosine (CER7-2′R,6R(d9)) has been used as an internal standard for qualitative analysis of stratum corneum (SC) ceramides in humans and mice by liquid chromatography–mass spectrometry (LC-MS)/MS.

Biochem/physiol Actions

6-Hydroxysphingosine is one of the sphingoid bases in skin.

Packaging

5 mL Amber Glass Screw Cap Vial (860837P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Principles and Practice of Skin Toxicology, 21-21 (2008)
Identification of lipids of the stratum corneum by high performance thin layer chromatography and mass spectrometry
Jamin EL, et al.
Eur. J. Mass Spectrom., 2018, 1469066718815380-1469066718815380 (2018)
Lipids and the Permeability and Antimicrobial Barriers of the Skin
Wertz Philip W
Journal of Lipids, 2018 (2018)
Momoko Kawana et al.
Journal of lipid research, 61(6), 884-895 (2020-04-09)
Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite

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