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700130P

Avanti

3β,24S-dihydroxy-5-cholestenoic acid

Avanti Research - A Croda Brand 700130P, powder

Synonym(s):

(25R)-cholest-5-en-26-oic acid,3β,24S-dihydroxy

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About This Item

Empirical Formula (Hill Notation):
C27H44O4
CAS Number:
Molecular Weight:
432.64
UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700130P-1mg)

manufacturer/tradename

Avanti Research - A Croda Brand 700130P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@H](C1)CC[C@](C1=CC2)(C)C3C2C(CC[C@@H]4[C@H](C)CC[C@H](O)[C@@H](C)C(O)=O)[C@]4(C)CC3

InChI key

XXUCPCOTPNGCMA-ODGUSDSXSA-N

General description

3β,24S-dihydroxy-5-cholestenoic acid is a cholestenoic acid (CA). The enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the synthesis of CA in the mitochondria.[1]

Biochem/physiol Actions

Cholestenoic acid (CA) is a ligand to nuclear receptor. Based on the structural features, CA may elicit neurotoxic or neuroprotective effects.[2] Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.[3]

Packaging

5 mL Amber Glass Screw Cap Vial (700130P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


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Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse
Crick PJ, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475-105475 (2019)
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S, et al
The Journal of Clinical Investigation, 124, 4829-4842 (2014)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143, 440-442 (2019)

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