The recommended storage temperature for item P49007 is room temperature. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
P49007
Piperine
≥97%
Synonym(s):
(E,E)-5-(3,4-Methylenedioxyphenyl)-2,4-pentadienoylpiperidide, 1-Piperoylpiperidine
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About This Item
Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
Molecular Weight:
285.34
Beilstein:
90741
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
form:
crystalline
powder, crystals or chunks
solid
powder, crystals or chunks
solid
Assay:
≥97%
Pricing and availability is not currently available.
Recommended Products
Quality Level
Assay
≥97%
form
crystalline
powder, crystals or chunks
solid
mp
131-135 °C (lit.)
SMILES string
O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3
InChI
1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChI key
MXXWOMGUGJBKIW-YPCIICBESA-N
Gene Information
human ... CYP3A4(1576)
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Application
Reactant for synthesis of:
- Dimeric amide alkaloids[1]
- Piperoyl-amino acid conjugates used for antileishmanial activity[2]
- Piperine derived amides with TRPV1 activity[3]
- Piperine analogues as S. aureus NorA efflux pump inhibitors[4]
- Bioactive conjugates of curcumin with antimicrobial and antiproliferative properties[5]
- Piperine derivatives for use as trypanocidal agents[6]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Jiu-Wang Yu et al.
Molecular diversity, 25(1), 233-248 (2020-03-05)
Piperine is the main active component of Piper longum L., which is also the main component of anti-sciatica Mongolian medicine Naru Sanwei pill. It has many pharmacological activities such as anti-inflammatory and immune regulation. This paper aims to preliminarily explore
V. R. S. Rao, et al.,
Tetrahedron, 67, 1885-1892 (2011)
Welisson da Silva Ferreira et al.
Bioorganic & medicinal chemistry, 16(6), 2984-2991 (2008-01-30)
We herein describe the synthesis and characterization of nine new 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine. We evaluate their toxic effects against the different evolutive forms of Trypanosoma cruzi, and the host cell (murine macrophages). The results obtained show that
Janine Zaugg et al.
Journal of natural products, 73(2), 185-191 (2010-01-21)
A plant extract library was screened for GABA(A) receptor activity making use of a two-microelectrode voltage clamp assay on Xenopus laevis oocytes. An ethyl acetate extract of black pepper fruits [Piper nigrum L. (Piperaceae) 100 microg/mL] potentiated GABA-induced chloride currents
Paul B Yaffe et al.
Experimental and molecular pathology, 94(1), 109-114 (2012-10-16)
Piperine, an alkaloid phytochemical found in the fruit of black and long pepper plants, is reported to inhibit the growth of cancer cells; however, the mechanism of action in human cancer cells is not clear. In this study we investigated
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piperine (5g) is currently on sale. When does it expire? How long can it be stored?
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