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911437

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 8, 8 NHBoc, 1 biotin (core), generation 3

Synonym(s):

Biotin-NHBoc dendron, Bis-MPA dendron

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About This Item

Empirical Formula (Hill Notation):
C117H192N10O52S
Molecular Weight:
2602.88
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

mol wt

generation 3

no. Surface Groups

8

color

colorless to white

storage temp.

−20°C

General description

  • Polymer architecture: Dendron
  • Generation: 3
  • Core functional group: Biotin
  • End Group Functionality: NHBoc
  • No. Surface Groups: 8
  • Calculated Mol. Wt.: 2602.9 g/mol
  • Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-Bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allows their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers are biocompatible and biodegradable, making them suitable for biomedical applications. The NHBoc-functionalized corona and Biotin-functionalized core of this product can be readily used in bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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