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Key Documents

900717

Sigma-Aldrich

N-((1S,2S)-1-((R)-4-Isopropyl-4,5-dihydrooxazol-2-yl)-2-methylbutyl)acetamide

≥95%

Synonym(s):

Chiral APAO ligand

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About This Item

Empirical Formula (Hill Notation):
C13H24N2O2
Molecular Weight:
240.34
UNSPSC Code:
12352200
NACRES:
NA.22
Pricing and availability is not currently available.

Assay

≥95%

form

powder

reaction suitability

reaction type: C-H Activation
reagent type: catalyst

color

white

functional group

amide

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1N=C([C@@H](NC(C)=O)[C@@H](CC)C)OC1

Application

Chiral bidentate ligand developed by Jin-Quan Yu′s lab for enantioselective borylation of C(sp3)–H bonds. This acetyl-protected aminomethyl oxazoline (APAO) ligand was demonstrated to be compatible with carbocyclic substrates with both α-tertiary and α-quaternary carbon centers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.

Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.

Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.

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