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762970

Sigma-Aldrich

Nicotinamide-2,4,5,6-d4

98 atom % D, 98% (CP)

Synonym(s):

Vitamin B3-2,4,5,6-d4

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About This Item

Empirical Formula (Hill Notation):
C6D4H2N2O
CAS Number:
347841-88-7
Molecular Weight:
126.15
MDL number:
MFCD01074140
UNSPSC Code:
12352005
PubChem Substance ID:
329767015

isotopic purity

98 atom % D

Assay

98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

color

white

mp

133 °C

mass shift

M+4

SMILES string

NC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)/i1D,2D,3D,4D

InChI key

DFPAKSUCGFBDDF-RHQRLBAQSA-N

Related Categories

General description

Nicotinamide (or niacinamide) is a form of vitamin B3 that can be used in a variety of therapeutic applications. It is found in meat, fish, nuts, and mushrooms, as well as in some vegetables. It is an amide derivative of nicotinic acid and is preferred in the treatment of pellagra, acne and skin cancer.
Nicotinamide-2,4,5,6-d4 is a deuterated vitamin B3 wherein C-2, C-4, C-5, and C-6 pyridine protons are replaced by deuterium.

Application

Nicotinamide-2,4,5,6-d4 can be used as a stable isotope internal standard for accurate data interpretation in samples by LC-MS.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Measurement of water-soluble B vitamins in infant formula by liquid chromatography/tandem mass spectrometry
Huang M, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 92(6), 1728-1738 (2009)
Contents of selected B vitamins in NIST SRM 3280 multivitamin/multielement tablets by liquid chromatography isotope dilution mass spectrometry
Chen P, et al.
Analytical and Bioanalytical Chemistry, 389(1), 343-347 (2007)
A review of nicotinamide: treatment of skin diseases and potential side effects
Rolfe HM
Journal of Cosmetic Dermatology, 13(4), 324-328 (2014)
Safety of high-dose nicotinamide: a review
Knip M, et al.
Diabetologia, 43(11), 1337-1345 (2000)

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