Skip to Content
Merck
All Photos(1)

Key Documents

709433

Sigma-Aldrich

Tetrahydrofuran-d8

99.5 atom % D, anhydrous

Synonym(s):

Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C4D8O
CAS Number:
Molecular Weight:
80.16
Beilstein:
111854
MDL number:

Pricing and availability is not currently available.

grade

anhydrous

isotopic purity

99.5 atom % D

Assay

95% (CP)

impurities

<50 ppm water

refractive index

n20/D 1.403 (lit.)

bp

65-66 °C (lit.)

mp

−106 °C (lit.)

density

0.985 g/mL at 25 °C (lit.)

mass shift

M+8

SMILES string

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

Looking for similar products? Visit Product Comparison Guide

General description

Tetrahydrofuran-d8 (THF-d8, TDF) is a deuterated NMR solvent useful in NMR-based research and analyses. It is an anhydrous solvent, which minimizes any interference from water peaks. It is useful in performing critical air- and moisture-sensitive NMR analysis. 1H NMR line shape analysis of the exchange rates of proton between methanol and acetic acid dissolved in THF-d8 was reported.[1] It participates as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.[2] Dynamic NMR spectroscopic study of 15N,15N′-dipentadeuterophenylformamidine (DPFA) has been studied in THF-d8.[3]

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

1.4 °F - closed cup

Flash Point(C)

-17 °C - closed cup


  • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Preparation and hydrogen-deuterium exchange of alkyl and hydride bis(trimethylsilyl) amido derivatives of the actinide elements.
    Simpson SJ, et al.
    Inorganic Chemistry, 20(9), 2991-2995 (1981)
    Dynamic NMR study of the interference between cyclic proton exchange, selfassociation and hindered rotation of diphenylformamidine in tetrahydrofuran.
    Meschede L, et al.
    Berichte der Bunsengesellschaft fur physikalische Chemie, 92(4), 469-485 (1988)
    NMR lineshape theory of superimposed intermolecular spin exchange reactions and its action to the system acetic acid/methanol/tetrahydrofuran-d8.
    Limbach HH.
    Journal of Magnetic Resonance, 36(3), 287-300 (1979)
    Alejandro G Lichtscheidl et al.
    Dalton transactions (Cambridge, England : 2003), 44(36), 16156-16163 (2015-08-22)
    The synthesis and full characterization, including Nuclear Magnetic Resonance (NMR) data ((1)H, (13)C{(1)H} and (119)Sn{(1)H}), for a series of Me3SnX (X = O-2,6-(t)Bu2C6H3 (), (Me3Sn)N(2,6-(i)Pr2C6H3) (), NH-2,4,6-(t)Bu3C6H2 (), N(SiMe3)2 (), NEt2, C5Me5 (), Cl, Br, I, and SnMe3) compounds in

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service