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667544

Sigma-Aldrich

Lithium chloride solution

0.5 M in anhydrous tetrahydrofuran

Synonym(s):

Lithium chloride, Lithium monochloride

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About This Item

Linear Formula:
LiCl
CAS Number:
7447-41-8
Molecular Weight:
42.39
MDL number:
MFCD00011078
UNSPSC Code:
12352302
PubChem Substance ID:
24884921
NACRES:
NA.22

concentration

0.5 M in anhydrous tetrahydrofuran

impurities

≤50 ppm water

density

0.913 g/mL at 25 °C

SMILES string

[Li+].[Cl-]

InChI

1S/ClH.Li/h1H;/q;+1/p-1

InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

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Application

Lithium chloride (LiCl) is a source of nucleophilic chloride anion and it can convert alcohols to alkyl chlorides. It catalyzes the ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA). LiCl solution is also used in the preparation of organozinc halides.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-4.0 °F - closed cup

Flash Point(C)

-20 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lithium Chloride.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
On-demand synthesis of organozinc halides under continuous flow conditions.
Berton, Mateo et al.
Nature Protocols, 13(1), 324-324 (2018)
Lekha Gupta et al.
The Journal of organic chemistry, 74(5), 2231-2233 (2009-02-05)
Ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA) in THF at -78 degrees C reveal substantial accelerations by as little as 0.5 mol % of LiCl (relative to LDA). Substrate dependencies suggest a specific range of reactivity
Qi Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14765-14770 (2013-08-22)
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved
Karla M Acevedo et al.
The Journal of biological chemistry, 289(16), 11007-11019 (2014-03-13)
Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics through the secretory pathway. We have previously reported that copper promotes a change in the cellular localization of APP. We now report that
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