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10924

Sigma-Aldrich

Sodium cyclohexanesulfonate

≥98.0% (T)

Synonym(s):

Cyclohexanesulfonic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C6H11NaO3S
CAS Number:
13893-74-8
Molecular Weight:
186.20
MDL number:
MFCD05865254
UNSPSC Code:
12352100
PubChem Substance ID:
57646855
NACRES:
NA.22

Assay

≥98.0% (T)

form

solid

impurities

≤1% water

SMILES string

[Na+].[O-]S(=O)(=O)C1CCCCC1

InChI

1S/C6H12O3S.Na/c7-10(8,9)6-4-2-1-3-5-6;/h6H,1-5H2,(H,7,8,9);/q;+1/p-1

InChI key

DIIKAKPJAGLSOD-UHFFFAOYSA-M

General description

Sodium cyclohexanesulfonate is a white to faintly beige powder to fine crystals with lump.

Application

Sodium cyclohexanesulfonate was used to study the influence of various hydrophobic ionic excipients on viscosity of concentrated solutions of therapeutic proteins. It was used as an ionic hydrophobic excipient that substantially decrease the viscosity of concentrated (300-400 mg/mL) aqueous solutions of bovine serum albumin and γ-globulin.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Wei Du et al.
Biotechnology and bioengineering, 108(3), 632-636 (2011-01-20)
Reducing viscosities of concentrated solutions of therapeutic proteins is important for their subcutaneous and intravenous delivery. Although inorganic salts and optimizing the pH were previously reported to dramatically lower the viscosity of a monoclonal antibody solution, herein we have determined

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