PSAP
prosaposin
Synonyms:
GLBA, SAP1
Species:
Human PSAP (5660), Mouse Psap (19156), Rat Psap (25524), dog PSAP (479240), chicken PSAP (395602), sheep PSAP (100135695), naked mole-rat Psap (101722989), Horse PSAP (100063520), cow PSAP (281433), domestic cat PSAP (101080406) ...More
UniProtKB ID:
Gene ID:
- Human(5660) Summary: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(19156) prosaposin
- Rat(25524) prosaposin
- dog(479240) prosaposin
- chicken(395602) prosaposin
- sheep(100135695) prosaposin
- naked mole-rat(101722989) prosaposin
- Horse(100063520) prosaposin
- cow(281433) prosaposin
- domestic cat(101080406) prosaposin
- domestic guinea pig(100713024) prosaposin
- Zebrafish(140811) prosaposin
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSAP antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
PSAP (PASE/4LJ) Mouse Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry