PIAS2
protein inhibitor of activated STAT, 2
Synonyms:
ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
Species:
Human PIAS2 (9063), Mouse Pias2 (17344), Rat Pias2 (83422), Zebrafish pias2 (564149), domestic guinea pig Pias2 (100718605), naked mole-rat Pias2 (101709303), sheep PIAS2 (101112782), cow PIAS2 (533403), Horse PIAS2 (100068879), domestic cat PIAS2 (101081835) ...More
UniProtKB ID:
Gene ID:
- Human(9063) Summary: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
- Mouse(17344) protein inhibitor of activated STAT 2
- Rat(83422) protein inhibitor of activated STAT, 2
- Zebrafish(564149) protein inhibitor of activated STAT, 2
- domestic guinea pig(100718605) protein inhibitor of activated STAT, 2
- naked mole-rat(101709303) protein inhibitor of activated STAT, 2
- sheep(101112782) protein inhibitor of activated STAT, 2
- cow(533403) protein inhibitor of activated STAT, 2
- Horse(100068879) protein inhibitor of activated STAT, 2
- domestic cat(101081835) protein inhibitor of activated STAT, 2
- dog(480147) protein inhibitor of activated STAT, 2
- chicken(416383) protein inhibitor of activated STAT, 2
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