ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonyms:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
UniProtKB ID:
Gene ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Product Number
Description
Species
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Species Reactivity
hamster, human
Application
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Monoclonal Anti-CD243 antibody produced in mouse, clone UIC2,
Species Reactivity
human
Application
flow cytometry
Cell Lines
Product Number
Description
Species
Kits
Product Number
Description
Species
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Species
mouse, rat, human
esiRNA
Product Number
Description
Species