T4887

T-2 Toxin

from Fusarium sp., powder, ≥98% (HPLC)

• Synonym(s): 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
• Empirical Formula (Hill Notation): C₂₄H₃₄O₉
• CAS Number: 21259-20-1
• Molecular Weight: 466.52
• Beilstein: 3575695
• EC Number: 244-297-7
• MDL number: MFCD00871255
• UNSPSC Code: 85151701
• PubChem Substance ID: 24900234
• NACRES: NA.77

Properties

• biological source: Fusarium sp.
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• availability: not available in USA, Japan
• color: white
• solubility: chloroform: soluble 9.80-10.20 mg/mL, clear, colorless to faintly yellow; DMSO: freely soluble; petroleum ether: slightly soluble
• storage temp.: −20°C
• SMILES string: [H][C@]12O[C@]3([H])[C@H](O)[C@@H](OC(C)=O)[C@](C)([C@@]1(COC(C)=O)C[C@H](OC(=O)CC(C)C)C(C)=C2)[C@]34CO4
• InChI: 1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1
• InChI key: BXFOFFBJRFZBQZ-QYWOHJEZSA-N

Description

Application

T-2 toxin can cause degenerative lesions in articular cartilage of rats⁸. Furthermore, immunotoxicity studies have reported that T-2 toxin can cause cell death in human lymphoid T cells and also induces cell membrane damage in B cells⁹.

Biochem/physiol Actions

The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

Quality

Chromatographically purified

Preparation Note

T-2 Toxin is soluble in chloroform at 9.80 - 10.20 mg/ml and yields a clear, colorless to faint yellow solution. Furthermore, the product is freely soluble in DMSO and slightly soluble in petroleum ether.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H315
• Precautionary Statements: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Skin Irrit. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves