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SML3891

Sigma-Aldrich

Letermovir

≥98% (HPLC)

Synonym(s):

(4S)-2-{8-Fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid, AIC 246, AIC-246, AIC246

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About This Item

Empirical Formula (Hill Notation):
C29H28F4N4O4
CAS Number:
917389-32-3
Molecular Weight:
572.55
MDL number:
MFCD22572725
UNSPSC Code:
41106609
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Letermovir (AIC246) is an orally active, potent and selective human cytomegalovirus (HCMV) DNA terminase complex inhibitor that blocks HCMV replication (EC50 = 0.9-3.1 nM among 17 clinial HCMV isolates; EC50 = 1.6-3.9 nM against 6 AD169-derived drug-resistant variants) by interfering with viral DNA cleavage/packaging. Letermovir exhibits little potency toward MCMV (Smith), RCMV (Maastricht), VZV (Oka), HSV-1 (166v VP22-GFP), HSV-2 (01-6332), HHV-6 (typeA-GS) or EBV (B95-8) (MCMV EC50 = 4.5 µM, all other EC50 >10 µM).

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd,H373

Hazard Classifications

Repr. 2 - STOT RE 2 Oral

Target Organs

Liver,Blood,spleen

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246
Antimicrobial Agents and Chemotherapy, 54(3), 1290-1297 (2010)
In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses
Antimicrobial Agents and Chemotherapy, 56(2), 1135-1137 (2012)
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase
Journal of virology, 85(20), 10884-10893 (2011)

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