Skip to Content
Merck
All Photos(1)

Documents

SML2187

Sigma-Aldrich

RL5a

≥98% (HPLC)

Synonym(s):

N2-[2-(2-Furanyl)-4-quinolinyl]-N1,N1-dimethyl-1,2-ethanediamine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C17H19N3O
CAS Number:
133671-66-6
Molecular Weight:
281.35
MDL number:
MFCD00929354
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19)

InChI key

CRGKLHXVNVZAPA-UHFFFAOYSA-N

Biochem/physiol Actions

RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNA, which is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Nicola J Gardner et al.
Cell chemical biology, 24(8), 981-992 (2017-08-07)
In late mitosis and G

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service