PLA0062

Rabbit anti-MCM4 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): CDC21, CDC21 homolog, CDC54, MCM4 minichromosome maintenance deficient 4 (S. cerevisiae), MGC33310, NKCD, NKGCD, P1-Cdc21, hCdc21, homolog of S. pombe cell devision cycle 21, minichromosome maintenance deficient 4
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: mouse, human
• technique(s): immunohistochemistry: 1:500-1:2,000; western blot: 1:2,000- 1:10,000
• accession no.: NP_005905.2
• UniProt accession no.: P33991
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rabbit ... MCM4(4173)

Description

Immunogen

The epitope recognized by PLA0062 maps to a region between residues 750 and 800 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM4 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM4 is phosphorylated by CDC2 kinase resulting in a reduction of helicase activity and chromatin binding.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable