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L5756

Sigma-Aldrich

Lithocholic acid 3-sulfate disodium salt hydrate

Synonym(s):

3α-Hydroxy-5β-cholan-24-oic acid 3-sulfate, Sulfolithocholic acid

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About This Item

Empirical Formula (Hill Notation):
C24H38Na2O6S · xH2O
CAS Number:
64936-81-8
Molecular Weight:
500.60 (anhydrous basis)
MDL number:
MFCD06200259
UNSPSC Code:
12161900
PubChem Substance ID:
24896416

Assay

≥95% (TLC)

storage temp.

−20°C

SMILES string

[Na+].[Na+].[H]O[H].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](C2)OS([O-])(=O)=O

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048H5005
105K5001
054K5016
100H7803

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H Takikawa et al.
Journal of gastroenterology and hepatology, 10(4), 383-386 (1995-07-01)
The absorption of lithocholate and its sulfate and glucuronide in rat jejunum and terminal ileum was studied. Tracer amounts of radiolabelled bile acids were administered to the ligated intestinal segments, and their absorption was monitored by biliary excretion through a
H Takikawa et al.
Digestive diseases and sciences, 40(8), 1792-1797 (1995-08-01)
Biliary excretion of lithocholate-3-sulfate is markedly impaired in EHBR. To examine the mechanism of biliary lithocholate-3-sulfate excretion in EHBR, the effects of colchicine treatment, a vesicular transport inhibitor, and infusion of taurocholate and organic anions were studied in EHBR and
D G Oelberg et al.
The American journal of physiology, 247(1 Pt 1), G112-G115 (1984-07-01)
Lithocholic acid (LCA) and its sulfate (LCS) and glucuronide (LCG) derivatives are potent cholestatic agents. During the course of LCG-induced cholestasis in rats, calcium (Ca) salts of LCG precipitate in bile. To characterize the affinity of bile salts for Ca
Cholic acid binding by anionic glutathione-S-transferase from human liver cytosol.
N R Pattinson
Biochemical and biophysical research communications, 102(1), 403-410 (1981-09-16)
K Finni et al.
Acta paediatrica Scandinavica, 72(2), 215-218 (1983-03-01)
The concentrations of the two secondary bile acids (deoxycholic (DCA) and sulpholithocholic (SLCA) acid) were determined by radioimmunoassays in the serum of infants and children at ages ranging from 1 hour to 15 years. The same bile acids were measured
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